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Richard Wilson

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Richard Wilson

Senior Research Fellow - Proteomics Mass Spectrometry
Central Science Laboratory

Room 334 (Level 3) , Chemistry Building

+61 3 6226 1718 (phone)

+61 3 6226 2494 (fax)

Richard.Wilson@utas.edu.au

Dr Richard Wilson is a Senior Research Fellow in the field of proteomics and manager of the CSL high resolution mass spectrometry facility. He is a biochemist with a long-standing interest in cartilage biology and pathology and more than a decade of experience in the application of proteomics in a wide range of biological contexts.

Richard has been an invited speaker at the International Cartilage Repair Society meeting and has given oral presentations at eight annual meetings the Matrix Biology Society of Australia and New Zealand, two Pan Pacific Connective Tissues Societies symposia and four symposia of the Federation of the European Connective Tissues Societies.

Biography

Richard was awarded his PhD in biochemistry from the University of Manchester (UK) in 1998. His thesis, entitled ‘The interaction of procollagen with endoplasmic reticulum resident proteins’ describes new roles for molecular chaperones in the biosynthesis, modification and assembly of extracellular matrix (ECM) proteins. Richard’s early post-doctoral research (1998-2005) at the University of Melbourne and Murdoch Children's Research Institute (MCRI) continued on the theme of ECM, investigating the effects of disease-causing mutations on protein assembly and secretion using in vitro and in vivo models for human skeletal dysplasias.

During the next stage of his post-doctoral career at MCRI as a Senior Research Officer (2005-2010), Richard developed an interest in proteomics as a novel approach to study musculoskeletal diseases. This led to the first proteomic analysis of mouse cartilage in 2006 and subsequent discovery of new proteins involved in cartilage development, ECM assembly and degeneration.

Richard has held his current appointment as manager of the Central Science Laboratory proteomics mass spectrometry facility at the University of Tasmania since 2011 and has an honorary appointment with the Musculoskeletal Research group at MCRI.

Career summary

Qualifications

DegreeThesis titleUniversityCountryDate of award
PhDThe interaction of procollagen with endoplasmic reticulum resident proteinsUniversity of ManchesterUKMay 26th 1998
BSc (Hons) University of ManchesterUKJuly 5th 1993

Memberships

Professional practice

  • Australasian Proteomics Society (2007- current)
  • Matrix Biology Society of Australia and New Zealand (2005- current)

Teaching

Teaching responsibility

View more on Dr Richard Wilson in WARP

Expertise

Richard’s primary research specialization is in the area of proteomics, the large-scale identification, quantification and characterization of proteins in complex biological samples. The core technology involved is high resolution tandem mass spectrometry combined with nano-flow UHPLC, which is used to separate and detect peptides. Proteins are identified by matching the acquired MS/MS data against protein sequence databases and statistical validation of peptide-spectrum matches, followed by quantitative analysis of the proteomics data using computational methods to determine differences between samples and treatment groups.

Richard has more than a decade of experience in proteomics research applications and is able to provide advice on experimental design, selection of methods for protein extraction and peptide sample preparation, together with a range of bioinformatics approaches to assist with biological interpretation of the results.

Further information about the proteomics and metabolomics capabilities of the high resolution mass spectrometry facility is available from the CSL proteomics web page: http://www.utas.edu.au/research/central-science-laboratory/facilities/proteomics-mass-spectrometry

Research Themes

The high resolution mass spectrometry facility is used to support research in four of the five UTas thematic areas: Environment, Resources & Sustainability; Better Health; Marine, Antarctic & Maritime and Data, Knowledge & Decisions.

A selection of completed, ongoing and proposed research projects that involve high-throughput proteomics and metabolomics analysis is listed below:

  • Cardio-metabolic research: application of metabolomics for biomarker detection, linking physiological measures of large artery function to underlying biochemical mechanisms e.g. during exercise (Menzies)
  • Neuroscience research: detailed characterization of neurons cultured using novel microfluidics systems; identifying protein expression and phosphorylation changes associated with axonal regeneration (Health)
  • Plant development: changes in amounts and covalent modification of proteins during perception and signal transduction of growth-regulating strigolactone hormones in plant cells (Biological Sciences)
  • Separation science: development of analyte extraction and separation chemistries with superior analytical capability for proteomics and metabolomics (Physical Sciences)
  • Microbial physiology: deep proteomic analysis of adaptive responses in food-borne pathogens (SLAF); physiology of sea-ice dwelling bacteria and diatoms (SLAF/IMAS)
  • Musculoskeletal biology: differential proteomic analysis of cartilage from wild-type and modified mice to investigate key molecules involved in skeletal development (Health).
  • Respiratory disease and development: characterization of new strains of pathogenic bacteria associated with cystic fibrosis; effects of vitamin D deficiency on lung development and function (Health)
  • Immunology and Tasmanian Devil Facial Tumour Disease (DFTD): identification of protein and metabolite biomarkers of DFTD; determination of the cellular origin of DFTD2 (Menzies/Health)
  • Cell stress and inflammation: investigation of cell stress mechanisms involved in the pathogenesis of colitis (Health)
  • Endocrinology: development of specific molecular biomarkers for diagnosis and prognosis in patients with multiple endocrine neoplasia, type I (MEN 1) (Health)
  • Salmon aquaculture: understanding the response to the pathogenic amoeba Neoparamoeba perurans in amoebic gill disease; development of improved feeding strategies (IMAS)
  • Agriculture: development of breed/cultivar and geographical markers for food authenticity testing (SLAF)

Fields of Research

  • Rheumatology and arthritis (320223)
  • Proteomics and intermolecular interactions (excl. medical proteomics) (310109)
  • Aquaculture (300501)
  • Pharmacology and pharmaceutical sciences (321499)
  • Separation science (340109)
  • Orthopaedics (320216)
  • Protein trafficking (310108)
  • Crop and pasture protection (incl. pests, diseases and weeds) (300409)
  • Cell metabolism (310103)
  • Animal immunology (310905)
  • Microbial ecology (310703)
  • Bacteriology (310701)
  • Cardiology (incl. cardiovascular diseases) (320101)
  • Respiratory diseases (320103)
  • Tumour immunology (320409)
  • Microbiology (310799)
  • Medical bacteriology (320701)
  • Medical biochemistry - proteins and peptides (incl. medical proteomics) (320506)
  • Proteins and peptides (340407)
  • Animal physiology - systems (310910)
  • Industrial microbiology (incl. biofeedstocks) (310605)
  • Basic pharmacology (321401)
  • Veterinary diagnosis and diagnostics (300904)
  • Medical biochemistry and metabolomics (320599)
  • Cancer cell biology (321101)
  • Veterinary immunology (300906)
  • Conservation and biodiversity (410401)
  • Chemical oceanography (370802)
  • Food sustainability (300606)
  • Nephrology and urology (320214)
  • Food packaging, preservation and processing (300604)
  • Cellular nervous system (320902)
  • Ophthalmology (321201)
  • Signal transduction (310111)
  • Cellular interactions (incl. adhesion, matrix, cell wall) (310105)
  • Flow analysis (340104)
  • Aquaculture and fisheries stock assessment (300502)
  • Gastroenterology and hepatology (320209)
  • Other chemical sciences (349999)
  • Proteomics and metabolomics (310205)
  • Fish physiology and genetics (300504)
  • Enzymes (310106)
  • Neurology and neuromuscular diseases (320905)
  • Molecular targets (321108)
  • Cell development, proliferation and death (310102)
  • Pharmaceutical sciences (321405)
  • Clinical pharmacology and therapeutics (321402)
  • Applied immunology (incl. antibody engineering, xenotransplantation and t-cell therapies) (320402)
  • Plant physiology (310806)
  • Biostatistics (490502)
  • Atmospheric composition, chemistry and processes (370104)
  • Analytical biochemistry (310101)
  • Radiation therapy (321110)
  • Gene expression (incl. microarray and other genome-wide approaches) (310505)
  • Infectious diseases (320211)
  • Transplantation immunology (320408)
  • Otorhinolaryngology (320217)
  • Environmental management (410404)
  • Ecosystem function (410203)
  • Zoology (310999)
  • Wildlife and habitat management (410407)

Research Objectives

  • Expanding knowledge in the health sciences (280112)
  • Clinical health (200199)
  • Expanding knowledge in the biological sciences (280102)
  • Aquaculture fin fish (excl. tuna) (100202)
  • Expanding knowledge in the chemical sciences (280105)
  • Field grown vegetable crops (260505)
  • Diagnosis of human diseases and conditions (200101)
  • Fisheries - aquaculture (100299)
  • Terrestrial biodiversity (180606)
  • Expanding knowledge in the environmental sciences (280111)
  • Control of pests, diseases and exotic species in terrestrial environments (180602)
  • Prevention of human diseases and conditions (200104)
  • Biodiversity in Antarctic and Southern Ocean environments (180404)
  • Food safety (200405)
  • Horticultural crops (260599)
  • Other health (209999)
  • Cheese (240503)
  • National security (140109)
  • Dairy products (240599)
  • Public health (excl. specific population health) (200499)
  • Treatment of human diseases and conditions (200105)
  • Measurement and assessment of marine water quality and condition (180505)
  • Aboriginal and Torres Strait Islander determinants of health (210301)
  • Aquaculture prawns (100205)
  • Non-dairy milk (241307)
  • Effects of climate change on Australia (excl. social impacts) (190504)
  • Ecosystem adaptation to climate change (190102)
  • Other environmental management (189999)
  • Expanding knowledge in the agricultural, food and veterinary sciences (280101)
  • Environmentally sustainable commercial services and tourism (110199)

Publications

Richard is co-author of ~50 research publications, including two first-author articles in the top-ranking proteomics journal, Molecular and Cellular Proteomics; five articles in Journal of Proteome Research that include two as corresponding author; two corresponding/senior author articles in Proteomics; six articles in the Journal of Biological Chemistry, including three as first author and one as senior/corresponding author.

Richard has a publication h-index of 16 and a cumulative total of 793 citations (sourced from WoS/Scopus).

Total publications

126

Highlighted publications

(4 outputs)
YearTypeCitationAltmetrics
2013Journal ArticleBrachvogel B, Zaucke F, Dave K, Norris EL, Stermann J, et al., 'Comparative Proteomic Analysis of Normal and Collagen IX Null Mouse Cartilage Reveals Altered Extracellular Matrix Composition and Novel Components of the Collagen IX Interactome', Journal of Biological Chemistry, 288, (19) ISSN 0021-9258 (2013) [Refereed Article]

DOI: 10.1074/jbc.M112.444810 [eCite] [Details]

Citations: Scopus - 43Web of Science - 40

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2011Journal ArticleWilson R, Readhead EL, Brachvogel B, Angelucci C, Zivkovic S, et al., 'Changes in the chondrocyte and extracellular matrix proteome during post-natal mouse cartilage development', Molecular and Cellular Proteomics, 11, (1) Article M111.014159. ISSN 1535-9476 (2011) [Refereed Article]

DOI: 10.1074/mcp.M111.014159 [eCite] [Details]

Citations: Scopus - 67Web of Science - 31

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2010Journal ArticleWilson R, 'The extracellular matrix: an underexplored but important proteome', Expert Review of Proteomics, 7, (6) pp. 803-806. ISSN 1478-9450 (2010) [Contribution to Refereed Journal]

DOI: 10.1586/epr.10.93 [eCite] [Details]

Citations: Scopus - 14Web of Science - 15

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2010Journal ArticleWilson R, Diseberg AF, Gordon L, Zivkovic S, Tatarczuch L, et al., 'Comprehensive profiling of cartilage extracellular matrix formation and maturation using sequential extraction and label-free quantitative proteomics', Molecular and Cellular Proteomics, 9, (6) pp. 1296-1313. ISSN 1535-9476 (2010) [Refereed Article]

DOI: 10.1074/mcp.M000014-MCP201 [eCite] [Details]

Citations: Scopus - 63Web of Science - 62

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Journal Article

(88 outputs)
YearCitationAltmetrics
2023Chen SH, Bose U, Broadbent JA, Fegan N, Wilson R, et al., 'Proteome analysis of Campylobacter jejuni poultry strain 2704 survival during 45 min exposure to peracetic acid', International Journal of Food Microbiology, 385 Article 110000. ISSN 0168-1605 (2023) [Refereed Article]

DOI: 10.1016/j.ijfoodmicro.2022.110000 [eCite] [Details]

Co-authors: Kocharunchitt C; Bowman JP

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2022Balotf S, Wilson CR, Tegg RS, Nichols DS, Wilson R, 'Large-scale protein and phosphoprotein profiling to explore potato resistance mechanisms to Spongospora subterranea infection', Frontiers in Plant Science, 13 Article 872901. ISSN 1664-462X (2022) [Refereed Article]

DOI: 10.3389/fpls.2022.872901 [eCite] [Details]

Citations: Scopus - 1Web of Science - 2

Co-authors: Balotf S; Wilson CR; Tegg RS; Nichols DS

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2022Balotf S, Wilson R, Nichols DS, Tegg RS, Wilson CR, 'Multi‑omics reveals mechanisms of resistance to potato root infection by Spongospora subterranea', Scientific Reports, 12 Article 10804. ISSN 2045-2322 (2022) [Refereed Article]

DOI: 10.1038/s41598-022-14606-y [eCite] [Details]

Citations: Scopus - 3Web of Science - 2

Co-authors: Balotf S; Nichols DS; Tegg RS; Wilson CR

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2022Balotf S, Wilson RR, Tegg RS, Nichols DS, Wilson CR, 'Shotgun proteomics as a powerful tool for the study of the proteomes of plants, their pathogens, and plant-pathogen interactions', Proteomes, 10, (1) Article 5. ISSN 2227-7382 (2022) [Refereed Article]

DOI: 10.3390/proteomes10010005 [eCite] [Details]

Citations: Scopus - 5Web of Science - 6

Co-authors: Balotf S; Tegg RS; Nichols DS; Wilson CR

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2022Chear S, Perry S, Wilson R, Bindoff A, Talbot J, et al., 'Lysosomal alterations and decreased electrophysiological activity in CLN3 disease patient-derived cortical neurons', Disease Models & Mechanisms, 15, (12) pp. 1-15. ISSN 1754-8403 (2022) [Refereed Article]

DOI: 10.1242/dmm.049651 [eCite] [Details]

Citations: Scopus - 1Web of Science - 1

Co-authors: Chear S; Perry S; Bindoff A; Talbot J; Vickers JC; King AE; Hewitt AW; Cook AL

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2022Doust YV, Bindoff A, Holloway OG, Wilson R, King AE, et al., 'Temporal changes in the microglial proteome of male and female mice after a diffuse brain injury using label-free quantitative proteomics', Glia pp. 1-24. ISSN 0894-1491 (2022) [Refereed Article]

DOI: 10.1002/glia.24313 [eCite] [Details]

Co-authors: Doust YV; Bindoff A; Holloway OG; King AE; Ziebell JM

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2022Esmaeili M, Carter CG, Wilson R, Walker SP, Miller MR, et al., 'Proteomic investigation of brain, liver and intestine in high feed intake and low feed intake Chinook salmon (Oncorhynchus tshawytscha)', Aquaculture, 551 Article 737915. ISSN 0044-8486 (2022) [Refereed Article]

DOI: 10.1016/j.aquaculture.2022.737915 [eCite] [Details]

Citations: Scopus - 7Web of Science - 7

Co-authors: Esmaeili M; Carter CG; Miller MR; Bridle AR

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2022Esmaeili M, Carter CG, Wilson R, Walker SP, Miller MR, et al., 'Protein metabolism in the liver and white muscle is associated with feed efficiency in Chinook salmon (Oncorhynchus tshawytscha) reared in seawater: evidence from proteomic analysis', Comparative Biochemistry and Physiology - Part D, 42 Article 100994. ISSN 1744-117X (2022) [Refereed Article]

DOI: 10.1016/j.cbd.2022.100994 [eCite] [Details]

Citations: Scopus - 2Web of Science - 2

Co-authors: Esmaeili M; Carter CG; Miller MR; Bridle AR; Symonds JE

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2022Espejo C, Patchett AL, Wilson R, Lyons AB, Woods GM, 'Challenges of an emerging disease: The evolving approach to diagnosing devil facial tumour disease', Pathogens, 11, (1) pp. 1-12. ISSN 2076-0817 (2022) [Refereed Article]

DOI: 10.3390/pathogens11010027 [eCite] [Details]

Co-authors: Espejo C; Patchett AL; Lyons AB; Woods GM

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2022Espejo C, Wilson R, Pye RJ, Ratcliffe JC, Ruiz-Aravena M, et al., 'Cathelicidin-3 associated with serum extracellular vesicles enables early diagnosis of a transmissible cancer', Frontiers in Immunology, 13 pp. 1-14. ISSN 1664-3224 (2022) [Refereed Article]

DOI: 10.3389/fimmu.2022.858423 [eCite] [Details]

Co-authors: Espejo C; Pye RJ; Ruiz-Aravena M; Wolfe BW; Hamede R; Woods GM; Lyons AB

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2022Meneghetti BV, Wilson R, Dias CK, Cadore NA, Klamt F, et al., 'p53 mutants G245S and R337H associated with the Li-Fraumeni syndrome regulate distinct metabolic pathways', Biochimie, 198, (2022) pp. 141-154. ISSN 0300-9084 (2022) [Refereed Article]

DOI: 10.1016/j.biochi.2022.03.003 [eCite] [Details]

Citations: Scopus - 2Web of Science - 2

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2022Sedeeq M, Maklad A, Dutta T, Feng Z, Wilson R, et al., 'T-type calcium channel inhibitors induce apoptosis in medulloblastoma cells associated with altered metabolic activity', Molecular Neurobiology, 59, (5) pp. 2932-2945. ISSN 0893-7648 (2022) [Refereed Article]

DOI: 10.1007/s12035-022-02771-0 [eCite] [Details]

Citations: Scopus - 1Web of Science - 1

Co-authors: Sedeeq M; Maklad A; Dutta T; Feng Z; Gueven N; Azimi I

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2022Wang JH, Chuang Y-F, Chen J, Singh V, Lin F-L, et al., 'An integrative multi-omics analysis reveals microRNA-143 as a potential therapeutic to attenuate retinal angiogenesis', Nucleic Acid Therapeutics, 32, (4) pp. 251-266. ISSN 2159-3337 (2022) [Refereed Article]

DOI: 10.1089/nat.2021.0111 [eCite] [Details]

Citations: Scopus - 1Web of Science - 1

Co-authors: Chuang Y-F; Singh V; Lin F-L; Hewitt AW

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2022Yu X, Wilson R, Balotf S, Tegg RS, Eyles A, et al., 'Comparative proteomic analysis of potato roots from resistant and susceptible cultivars to Spongospora subterranea zoospore root attachment in vitro', Molecules: A Journal of Synthetic Organic and Natural Product Chemistry, 27, (18) Article 6024. ISSN 1420-3049 (2022) [Refereed Article]

DOI: 10.3390/molecules27186024 [eCite] [Details]

Citations: Scopus - 1

Co-authors: Yu X; Balotf S; Tegg RS; Eyles A; Wilson CR

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2021Atkinson RAK, Fair HL, Wilson R, Vickers JC, King AE, 'Effects of TDP-43 overexpression on neuron proteome and morphology in vitro', Molecular and Cellular Neurosciences, 114 pp. 1-11. ISSN 1044-7431 (2021) [Refereed Article]

DOI: 10.1016/j.mcn.2021.103627 [eCite] [Details]

Co-authors: Atkinson RAK; Fair HL; Vickers JC; King AE

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2021Balotf S, Wilson R, Tegg RS, Nichols DS, Wilson CR, 'Quantitative proteomics provides an insight into germination-related proteins in the obligate biotrophic plant pathogen Spongospora subterranea', Environmental Microbiology Reports pp. 1-12. ISSN 1758-2229 (2021) [Refereed Article]

DOI: 10.1111/1758-2229.12955 [eCite] [Details]

Citations: Scopus - 7Web of Science - 7

Co-authors: Balotf S; Tegg RS; Nichols DS; Wilson CR

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2021Balotf S, Wilson R, Tegg RS, Nichols DS, Wilson CR, 'In planta transcriptome and proteome profiles of Spongospora subterranea in resistant and susceptible host environments illuminates regulatory principles underlying host-pathogen interaction', Biology, 10, (9) Article 840. ISSN 2079-7737 (2021) [Refereed Article]

DOI: 10.3390/biology10090840 [eCite] [Details]

Citations: Scopus - 8Web of Science - 8

Co-authors: Balotf S; Tegg RS; Nichols DS; Wilson CR

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2021Bubb K, Holzer T, Nolte JL, Kruger M, Wilson R, et al., 'Mitochondrial respiratory chain function promotes extracellular matrix integrity in cartilage', Journal of Biological Chemistry, 297, (4) Article 101224. ISSN 1083-351X (2021) [Refereed Article]

DOI: 10.1016/j.jbc.2021.101224 [eCite] [Details]

Citations: Scopus - 5Web of Science - 4

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2021Esmaeili M, Carter CG, Wilson R, Walker SP, Miller MR, et al., 'Proteomic investigation of liver and white muscle in efficient and inefficient Chinook salmon (Oncorhynchus tshawytscha): fatty acid metabolism and protein turnover drive feed efficiency', Aquaculture, 542 Article 736855. ISSN 0044-8486 (2021) [Refereed Article]

DOI: 10.1016/j.aquaculture.2021.736855 [eCite] [Details]

Citations: Scopus - 15Web of Science - 14

Co-authors: Esmaeili M; Carter CG; Miller MR; Bridle A; Symonds JE

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2021Espejo C, Wilson R, Willms E, Ruiz-Aravena M, Pye RJ, et al., 'Extracellular vesicle proteomes of two transmissible cancers of Tasmanian devils reveal tenascin-C as a serum-based differential diagnostic biomarker', Cellular and Molecular Life Sciences, 78, (23) pp. 7537-7555. ISSN 1420-682X (2021) [Refereed Article]

DOI: 10.1007/s00018-021-03955-y [eCite] [Details]

Citations: Scopus - 5Web of Science - 5

Co-authors: Espejo C; Ruiz-Aravena M; Pye RJ; Jones M; Woods GM; Lyons AB

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2021Rasouli F, Kiani-Pouya A, Shabala L, Li L, Tahir A, et al., 'Salinity effects on guard cell proteome in Chenopodium quinoa', International Journal of Molecular Sciences, 22, (1) Article 428. ISSN 1422-0067 (2021) [Refereed Article]

DOI: 10.3390/ijms22010428 [eCite] [Details]

Citations: Scopus - 16Web of Science - 15

Co-authors: Kiani-Pouya A; Shabala L; Shabala S

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2021Shah SS, Al-Naseri A, Rouch D, Bowman JP, Wilson R, et al., 'Properties of an acid-tolerant, persistent Cheddar cheese isolate, Lacticaseibacillus paracasei GCRL163', Journal of Industrial Microbiology and Biotechnology, 48, (9-10) Article kuab070. ISSN 1367-5435 (2021) [Refereed Article]

DOI: 10.1093/jimb/kuab070 [eCite] [Details]

Co-authors: Shah SS; Al-Naseri A; Bowman JP; Baker AL; Britz ML

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2021Song Y, Walters EH, Abramson MJ, Bowatte G, Bui DS, et al., 'Protein levels, air pollution and vitamin D deficiency: links with allergy', ERJ Open Research, 7, (4) pp. 1-4. ISSN 2312-0541 (2021) [Refereed Article]

DOI: 10.1183/23120541.00237-2021 [eCite] [Details]

Co-authors: Song Y; Walters EH; Nichols DS; Zosky GR

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2020Adu KT, Wilson R, Baker AL, Bowman J, Britz ML, 'Prolonged heat stress of Lactobacillus paracasei GCRL163 improves binding to human colorectal adenocarcinoma HT-29 cells and modulates the relative abundance of secreted and cell surface-located proteins', Journal of Proteome Research, 19, (4) pp. 1824-1846. ISSN 1535-3893 (2020) [Refereed Article]

DOI: 10.1021/acs.jproteome.0c00107 [eCite] [Details]

Citations: Scopus - 3Web of Science - 3

Co-authors: Baker AL; Bowman J; Britz ML

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2020Balotf S, Wilson R, Tegg RS, Nichols DS, Wilson CR, 'Optimisation of sporosori purification and protein extraction techniques for the biotrophic protozoan plant pathogen Spongospora subterranea', Molecules, 25, (14) Article 3109. ISSN 1420-3049 (2020) [Refereed Article]

DOI: 10.3390/molecules25143109 [eCite] [Details]

Citations: Scopus - 9Web of Science - 9

Co-authors: Balotf S; Tegg RS; Nichols DS; Wilson CR

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2020Georgieva VS, Etich J, Bluhm B, Zhu M, Frie C, et al., 'Ablation of the miRNA cluster 24 has profound effects on extracellular matrix protein abundance in cartilage', International Journal of Molecular Sciences, 21, (11) Article 4112. ISSN 1422-0067 (2020) [Refereed Article]

DOI: 10.3390/ijms21114112 [eCite] [Details]

Citations: Scopus - 4Web of Science - 5

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2020Pandigamage P, Wilson R, Quirino JP, 'A simple apparatus for electrokinetic removal of sodium dodecyl sulfate from protein digests', Journal of Chromatography A, 1628 Article 461443. ISSN 0021-9673 (2020) [Refereed Article]

DOI: 10.1016/j.chroma.2020.461443 [eCite] [Details]

Citations: Scopus - 1Web of Science - 1

Co-authors: Pandigamage P; Quirino JP

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2020Rasouli F, Kiani-Pouya A, Li L, Zhang H, Chen Z, et al., 'Sugar beet (Beta vulgaris) guard cells responses to salinity stress: a proteomic analysis', International Journal of Molecular Sciences, 21, (7) Article 2331. ISSN 1422-0067 (2020) [Refereed Article]

DOI: 10.3390/ijms21072331 [eCite] [Details]

Citations: Scopus - 10Web of Science - 10

Co-authors: Kiani-Pouya A; Shabala S

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2020Yen S, Song Y, Preissner M, Bennett E, Wilson R, et al., 'The proteomic response is linked to regional lung volumes in ventilator-induced lung injury', Journal of Applied Physiology, 129, (4) pp. 837-845. ISSN 8750-7587 (2020) [Refereed Article]

DOI: 10.1152/japplphysiol.00097.2020 [eCite] [Details]

Citations: Scopus - 5Web of Science - 4

Co-authors: Yen S; Song Y; Bennett E; Pavez M; Dargaville PA; Zosky GR

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2019Kennedy F, Martin A, Bowman JP, Wilson R, McMinn A, 'Dark metabolism: a molecular insight into how the Antarctic sea-ice diatom Fragilariopsis cylindrus survives long-term darkness', New Phytologist, 223, (2) pp. 675-691. ISSN 0028-646X (2019) [Refereed Article]

DOI: 10.1111/nph.15843 [eCite] [Details]

Citations: Scopus - 19Web of Science - 18

Co-authors: Kennedy F; Martin A; Bowman JP; McMinn A

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2019Latham RD, Torrado M, Atto B, Walshe JL, Wilson R, et al., 'A heme-binding protein produced by Haemophilus haemolyticus inhibits non-typeable Haemophilus influenzae', Molecular Microbiology, 113, (2) pp. 381-398. ISSN 0950-382X (2019) [Refereed Article]

DOI: 10.1111/mmi.14426 [eCite] [Details]

Citations: Scopus - 10Web of Science - 10

Co-authors: Latham RD; Atto B; Tristram S; Gell DA

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2019Patchett AL, Coorens THH, Darby J, Wilson R, McKay MJ, et al., 'Two of a kind: transmissible Schwann cell cancers in the endangered Tasmanian devil (Sarcophilus harrisii)', Cellular and Molecular Life Sciences, 77 pp. 1847-1858. ISSN 1420-682X (2019) [Refereed Article]

DOI: 10.1007/s00018-019-03259-2 [eCite] [Details]

Citations: Scopus - 16Web of Science - 15

Co-authors: Patchett AL; Darby J; Pye RJ; Flies AS; Lyons AB; Woods GM; Tovar C

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2019Wilson R, Gundamaraju R, Vemuri R, Angelucci C, Geraghty D, et al., 'Identification of key pro-survival proteins in isolated colonic goblet cells of Winnie, a murine model of spontaneous colitis', Inflammatory Bowel Diseases, 26, (1) pp. 80-92. ISSN 1536-4844 (2019) [Refereed Article]

DOI: 10.1093/ibd/izz179 [eCite] [Details]

Citations: Scopus - 5Web of Science - 5

Co-authors: Vemuri R; Angelucci C; Geraghty D; Guven N; Eri RD

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2018Adu KT, Wilson R, Nichols DS, Baker AL, Bowman JP, et al., 'Proteomic analysis of Lactobacillus casei GCRL163 cell-free extracts reveals a SecB homolog and other biomarkers of prolonged heat stress', PLoS One, 13, (10) Article e0206317. ISSN 1932-6203 (2018) [Refereed Article]

DOI: 10.1371/journal.pone.0206317 [eCite] [Details]

Citations: Scopus - 11Web of Science - 10

Co-authors: Nichols DS; Baker AL; Bowman JP; Britz ML

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2018Currivan SA, Chen WQ, Wilson R, Sanz Rodriguez E, Upadhyay N, et al., 'Multi-lumen capillary based trypsin micro-reactor for the rapid digestion of proteins', Analyst, 143, (20) pp. 4944-4953. ISSN 0003-2654 (2018) [Refereed Article]

DOI: 10.1039/c8an01330f [eCite] [Details]

Citations: Scopus - 9Web of Science - 9

Co-authors: Currivan SA; Sanz Rodriguez E; Upadhyay N; Nesterenko PN; Paull B

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2018Hostrup M, Onslev J, Jacobson G, Wilson R, Bangsbo J, 'Chronic β2-adrenoceptor agonist treatment alters muscle proteome and functional adaptations induced by high intensity training in young men', Journal of Physiology, 596, (2) pp. 231-252. ISSN 0022-3751 (2018) [Refereed Article]

DOI: 10.1113/JP274970 [eCite] [Details]

Citations: Scopus - 30Web of Science - 27

Co-authors: Jacobson G

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2018Nuez-Ortin WG, Carter CG, Nichols PD, Cooke IR, Wilson R, 'Liver proteome response of pre-harvest Atlantic salmon following exposure to elevated temperature', BMC Genomics, 19 Article 133. ISSN 1471-2164 (2018) [Refereed Article]

DOI: 10.1186/s12864-018-4517-0 [eCite] [Details]

Citations: Scopus - 33Web of Science - 26

Co-authors: Nuez-Ortin WG; Carter CG; Nichols PD

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2018Patchett AL, Wilson R, Charlesworth JC, Corcoran LM, Papenfuss AT, et al., 'Transcriptome and proteome profiling reveals stress-induced expression signatures of imiquimod-treated Tasmanian devil facial tumor disease (DFTD) cells', OncoTarget, 9, (22) pp. 15895-15914. ISSN 1949-2553 (2018) [Refereed Article]

DOI: 10.18632/oncotarget.24634 [eCite] [Details]

Citations: Scopus - 9

Co-authors: Patchett AL; Charlesworth JC; Lyons AB; Woods GM; Tovar C

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2018Tovar C, Patchett AL, Kim V, Wilson R, Darby J, et al., 'Heat shock proteins expressed in the marsupial Tasmanian devil are potential antigenic candidates in a vaccine against devil facial tumour disease', PLoS ONE, 13, (4) Article e0196469. ISSN 1932-6203 (2018) [Refereed Article]

DOI: 10.1371/journal.pone.0196469 [eCite] [Details]

Citations: Scopus - 4Web of Science - 4

Co-authors: Tovar C; Patchett AL; Darby J; Lyons AB; Woods GM

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2018Wanandy T, Wilson R, Gell D, Rose HE, Gueven N, et al., 'Towards complete identification of allergens in Jack Jumper (Myrmecia pilosula) ant venom and their clinical relevance: An immunoproteomic approach', Clinical and Experimental Allergy, 48, (9) pp. 1222-1234. ISSN 1365-2222 (2018) [Refereed Article]

DOI: 10.1111/cea.13224 [eCite] [Details]

Citations: Scopus - 10Web of Science - 10

Co-authors: Wanandy T; Gell D; Gueven N; Davies NW; Brown SGA

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2017Karu N, Hamede Ross RK, Wilson R, 'That Old Devil Called Tasmanian', The Column, 13, (2) pp. 2-5. ISSN 1471-6577 (2017) [Professional, Non Refereed Article]

[eCite] [Details]

Co-authors: Karu N; Hamede Ross RK

2017Nuez Ortin W, Carter CG, Wilson R, Cooke I, Amoroso G, et al., 'Triploid Atlantic salmon shows similar performance, fatty acid composition and proteome response to diploids during early freshwater rearing', Comparative Biochemistry and Physiology - Part D: Genomics and Proteomics, 22 pp. 67-77. ISSN 1744-117X (2017) [Refereed Article]

DOI: 10.1016/j.cbd.2017.02.005 [eCite] [Details]

Citations: Scopus - 13Web of Science - 13

Co-authors: Nuez Ortin W; Carter CG; Amoroso G; Cobcroft JM; Nichols PD

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2017Sandron S, Davies NW, Wilson R, Rojas Cardona A, Haddad PR, et al., 'Fractionation of dissolved organic matter on coupled reversed-phase monolithic columns and characterisation using reversed-phase liquid chromatography-high resolution mass spectrometry', Chromatographia, 81, (2) pp. 203-213. ISSN 0009-5893 (2017) [Refereed Article]

DOI: 10.1007/s10337-017-3324-0 [eCite] [Details]

Citations: Scopus - 10Web of Science - 8

Co-authors: Sandron S; Davies NW; Rojas Cardona A; Haddad PR; Nesterenko PN; Paull B

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2016Chen L, Wilson R, Bennett E, Zosky GR, 'Identification of vitamin D sensitive pathways during lung development', Respiratory Research, 17 pp. 1-11. ISSN 1465-993X (2016) [Refereed Article]

DOI: 10.1186/s12931-016-0362-3 [eCite] [Details]

Citations: Scopus - 34Web of Science - 31

Co-authors: Chen L; Bennett E; Zosky GR

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2016Karu N, Wilson R, Hamede R, Jones M, Woods GM, et al., 'Discovery of biomarkers for Tasmanian devil cancer (DFTD) by metabolic profiling of serum', Journal of Proteome Research, 15, (10) pp. 3827-3840. ISSN 1535-3907 (2016) [Refereed Article]

DOI: 10.1021/acs.jproteome.6b00629 [eCite] [Details]

Citations: Scopus - 12Web of Science - 12

Co-authors: Karu N; Hamede R; Jones M; Woods GM; Hilder EF; Shellie RA

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2016Kosiah HJ, Last K, Rogerson FM, Golub SB, Gauci SJ, et al., 'A disintegrin and metalloproteinase with thrombospondin motifs-5 (ADAMTS-5) forms catalytically active oligomers', Journal of Biological Chemistry, 291, (7) pp. 3197-3208. ISSN 1083-351X (2016) [Refereed Article]

DOI: 10.1074/jbc.M115.704817 [eCite] [Details]

Citations: Scopus - 10Web of Science - 8

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2016Mahbub P, Wilson R, Nesterenko PN, 'Ultra-fast continuous-flow photo degradation of organic peroxide explosives for their efficient conversion into hydrogen peroxide and possible application', Propellants, Explosives, Pyrotechnics, 41, (4) pp. 757-763. ISSN 0721-3115 (2016) [Refereed Article]

DOI: 10.1002/prep.201500309 [eCite] [Details]

Citations: Scopus - 4Web of Science - 3

Co-authors: Mahbub P; Nesterenko PN

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2016Nikolic SB, Edwards LM, Karpievitch YV, Wilson R, Horne J, et al., 'Serum metabolic profile predicts adverse central haemodynamics in patients with type 2 diabetes mellitus', Acta Diabetologica, 53 pp. 367-375. ISSN 1432-5233 (2016) [Refereed Article]

DOI: 10.1007/s00592-015-0802-4 [eCite] [Details]

Citations: Scopus - 4Web of Science - 3

Co-authors: Nikolic SB; Karpievitch YV; Horne J; Adams MJ; Sharman JE

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2016Nuez-Ortin W, Carter CG, Nichols PD, Wilson R, 'Sequential protein extraction as an efficient method for improved proteome coverage in larvae of Atlantic salmon (Salmo salar)', Proteomics, 16, (14) pp. 2043-2047. ISSN 1615-9861 (2016) [Refereed Article]

DOI: 10.1002/pmic.201600051 [eCite] [Details]

Citations: Scopus - 4Web of Science - 3

Co-authors: Nuez-Ortin W; Carter CG

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2016Nuez-Ortin WG, Carter CG, Wilson R, Cooke I, Nichols PD, 'Preliminary validation of a high docosahexaenoic acid (DHA) and -linolenic acid (ALA) dietary oil blend: tissue fatty acid composition and liver proteome response in Atlantic salmon (Salmo salar) smolts', PLoS One, 13, (5) Article e0197800. ISSN 1932-6203 (2016) [Refereed Article]

DOI: 10.1371/journal.pone.0161513 [eCite] [Details]

Citations: Scopus - 7Web of Science - 6

Co-authors: Nuez-Ortin WG; Carter CG; Nichols PD

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2016Rojas A, Sandron S, Wilson R, Davies NW, Haddad PR, et al., 'Simple, quantitative method for low molecular weight dissolved organic matter extracted from natural waters based upon high performance counter-current chromatography', Analytica Chimica Acta, 909 pp. 129-138. ISSN 0003-2670 (2016) [Refereed Article]

DOI: 10.1016/j.aca.2016.01.003 [eCite] [Details]

Citations: Scopus - 6Web of Science - 6

Co-authors: Rojas A; Sandron S; Davies NW; Haddad PR; Shellie RA; Nesterenko PN; Paull B

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2016Wilson R, Golub SB, Rowley L, Angelucci C, Karpievitch YV, et al., 'Novel elements of the chondrocyte stress response identified using an in vitro model of mouse cartilage degradation', Journal of Proteome Research, 15, (3) pp. 1033-1050. ISSN 1535-3907 (2016) [Refereed Article]

DOI: 10.1021/acs.jproteome.5b01115 [eCite] [Details]

Citations: Scopus - 25Web of Science - 24

Co-authors: Karpievitch YV

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2015Cameron TL, Gresshoff IL, Bell KM, Pirog KA, Sampurno L, et al., 'Cartilage-specific ablation of XBP1 signaling in mouse results in a chondrodysplasia characterized by reduced chondrocyte proliferation and delayed cartilage maturation and mineralization', Osteoarthritis and Cartilage, 23, (4) pp. 661-670. ISSN 1063-4584 (2015) [Refereed Article]

DOI: 10.1016/j.joca.2015.01.001 [eCite] [Details]

Citations: Scopus - 34Web of Science - 32

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2015Davies NW, Sandron S, Nesterenko PN, Paull B, Wilson R, et al., 'Comment on 'Structural characterization of dissolved organic matter: a review of current techniques for isolation and analysis' by E. C. Minor, M. M. Swenson, B. M. Mattson, and A. R. Oyler, Environ. Sci.: Processes Impacts, 2014, 16, 2064', Environmental Science: Processes and Impacts, 17, (2) pp. 495-496. ISSN 2050-7887 (2015) [Letter or Note in Journal]

DOI: 10.1039/c4em00631c [eCite] [Details]

Citations: Scopus - 6Web of Science - 6

Co-authors: Davies NW; Sandron S; Nesterenko PN; Paull B; Haddad P; Shellie R; Rojas Cardona A

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2015Feng S, Powell SM, Wilson R, Bowman JP, 'Proteomic insight into functional changes of proteorhodopsin-containing bacterial species Psychroflexus torquis under different illumination and salinity levels', Journal of Proteome Research, 14, (9) pp. 3848-3858. ISSN 1535-3893 (2015) [Refereed Article]

DOI: 10.1021/acs.jproteome.5b00241 [eCite] [Details]

Citations: Scopus - 11Web of Science - 9

Co-authors: Powell SM; Bowman JP

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2015Mata MM, da Silva WP, Wilson R, Lowe E, Bowman JP, 'Attached and planktonic Listeria monocytogenes global proteomic responses and associated influence of strain genetics and temperature', Journal of Proteome Research, 14, (2) pp. 1161-1173. ISSN 1535-3893 (2015) [Refereed Article]

DOI: 10.1021/pr501114e [eCite] [Details]

Citations: Scopus - 11Web of Science - 10

Co-authors: Bowman JP

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2015Sandron S, Rojas A, Wilson R, Davies NW, Haddad PR, et al., 'Chromatographic methods for the isolation, separation and characterisation of dissolved organic matter', Environmental Science Processes and Impacts, 17, (9) pp. 1531-1567. ISSN 2050-7887 (2015) [Refereed Article]

DOI: 10.1039/c5em00223k [eCite] [Details]

Citations: Scopus - 52Web of Science - 49

Co-authors: Sandron S; Rojas A; Davies NW; Haddad PR; Shellie RA; Nesterenko PN; Paull B

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2014Feng S, Powell SM, Wilson R, Bowman JP, 'Extensive gene acquisition in the extremely psychrophilic bacterial species Psychroflexus torquis and the link to sea-ice ecosystem specialism', Genome Biology and Evolution, 6, (1) pp. 133-148. ISSN 1759-6653 (2014) [Refereed Article]

DOI: 10.1093/gbe/evt209 [eCite] [Details]

Citations: Scopus - 42Web of Science - 35

Co-authors: Feng S; Powell SM; Bowman JP

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2014Karpievitch YV, Nikolic SB, Wilson R, Sharman JE, Edwards LM, 'Metabolomics Data Normalization with EigenMS', PLoS One, 9, (12) Article e116221. ISSN 1932-6203 (2014) [Refereed Article]

DOI: 10.1371/journal.pone.0116221 [eCite] [Details]

Citations: Scopus - 83Web of Science - 80

Co-authors: Karpievitch YV; Nikolic SB; Sharman JE

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2014Musgrove RE, Horne H, Wilson R, King AE, Edwards LM, et al., 'The metabolomics of alpha-synuclein (SNCA) gene deletion and mutation in mouse brain', Metabolomics, 10, (1) pp. 114-122. ISSN 1573-3882 (2014) [Refereed Article]

DOI: 10.1007/s11306-013-0561-6 [eCite] [Details]

Citations: Scopus - 11Web of Science - 10

Co-authors: Musgrove RE; Horne H; King AE; Edwards LM; Dickson TC

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2014Nikolic SB, Wilson R, Hare JL, Adams MJ, Edwards LM, et al., 'Spironolactone reduces aortic stiffness via blood pressure-dependent effects of canrenoate', Metabolomics, 10, (1) pp. 105-113. ISSN 1573-3882 (2014) [Refereed Article]

DOI: 10.1007/s11306-013-0557-2 [eCite] [Details]

Citations: Scopus - 6Web of Science - 6

Co-authors: Nikolic SB; Adams MJ; Sharman JE

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2014Sandron S, Wilson R, Larragy R, McCaul MV, Nesterenko PN, et al., 'Investigation into dissolved neutral sugars and their microbial conversion in natural and artificially produced dissolved organic matter using ion chromatography with pulsed amperometric detection and reversed-phase liquid chromatography-high resolution mass spectrometry', Analytical Methods, 6, (1) pp. 107-114. ISSN 1759-9660 (2014) [Refereed Article]

DOI: 10.1039/c3ay41549j [eCite] [Details]

Citations: Scopus - 5Web of Science - 4

Co-authors: Sandron S; Nesterenko PN; Paull B

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2014Valdenegro-Vega VA, Crosbie P, Bridle A, Leef M, Wilson R, et al., 'Differentially expressed proteins in gill and skin mucus of Atlantic salmon (Salmo salar) affected by amoebic gill disease', Fish and Shellfish Immunology, 40, (1) pp. 69-77. ISSN 1050-4648 (2014) [Refereed Article]

DOI: 10.1016/j.fsi.2014.06.025 [eCite] [Details]

Citations: Scopus - 63Web of Science - 57

Co-authors: Valdenegro-Vega VA; Crosbie P; Bridle A; Leef M; Nowak BF

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2013Al-Naseri A, Bowman JP, Wilson R, Nilsson RE, Britz ML, 'Impact of lactose starvation on the physiology of Lactobacillus casei GCRL 163 in the presence or absence of Tween 80', Journal of Proteome Research, 12, (11) pp. 5315-5322. ISSN 1535-3893 (2013) [Refereed Article]

DOI: 10.1021/pr400661g [eCite] [Details]

Citations: Scopus - 31Web of Science - 30

Co-authors: Al-Naseri A; Bowman JP; Nilsson RE; Britz ML

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2013Brachvogel B, Zaucke F, Dave K, Norris EL, Stermann J, et al., 'Comparative Proteomic Analysis of Normal and Collagen IX Null Mouse Cartilage Reveals Altered Extracellular Matrix Composition and Novel Components of the Collagen IX Interactome', Journal of Biological Chemistry, 288, (19) ISSN 0021-9258 (2013) [Refereed Article]

DOI: 10.1074/jbc.M112.444810 [eCite] [Details]

Citations: Scopus - 43Web of Science - 40

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2013Feng S, Powell SM, Wilson R, Bowman JP, 'Light-stimulated growth of proteorhodopsin-bearing sea-ice psychrophile Psychroflexus torquis is salinity dependent', The ISME Journal, 7, (11) pp. 2206-2213. ISSN 1751-7362 (2013) [Refereed Article]

DOI: 10.1038/ismej.2013.97 [eCite] [Details]

Citations: Scopus - 48Web of Science - 43

Co-authors: Powell SM; Bowman JP

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2012Edwards LM, Lawler NG, Nikolic SB, Peters JM, Horne J, et al., 'Metabolomics reveals increased isoleukotoxin diol (12,13-DHOME) in human plasma after acute Intralipid infusion', Journal of Lipid Research, 53, (9) pp. 1979-1986. ISSN 0022-2275 (2012) [Refereed Article]

DOI: 10.1194/jlr.P027706 [eCite] [Details]

Citations: Scopus - 27Web of Science - 26

Co-authors: Lawler NG; Nikolic SB; Peters JM; Horne J; Davies NW; Sharman JE

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2012Wilson R, 'Umbilical cord stromal cell differentiation: little correlation with known markers of the chondrocyte phenotype or cartilage extracellular matrix', Molecular and Cellular Proteomics, 11, (4) pp. L111.010496 1-2. ISSN 1535-9476 (2012) [Letter or Note in Journal]

DOI: 10.1074/mcp.L111.010496 [eCite] [Details]

Citations: Scopus - 1Web of Science - 1

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2011Wilson R, Readhead EL, Brachvogel B, Angelucci C, Zivkovic S, et al., 'Changes in the chondrocyte and extracellular matrix proteome during post-natal mouse cartilage development', Molecular and Cellular Proteomics, 11, (1) Article M111.014159. ISSN 1535-9476 (2011) [Refereed Article]

DOI: 10.1074/mcp.M111.014159 [eCite] [Details]

Citations: Scopus - 67Web of Science - 31

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2010Wilson R, 'The extracellular matrix: an underexplored but important proteome', Expert Review of Proteomics, 7, (6) pp. 803-806. ISSN 1478-9450 (2010) [Contribution to Refereed Journal]

DOI: 10.1586/epr.10.93 [eCite] [Details]

Citations: Scopus - 14Web of Science - 15

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2010Wilson R, Diseberg AF, Gordon L, Zivkovic S, Tatarczuch L, et al., 'Comprehensive profiling of cartilage extracellular matrix formation and maturation using sequential extraction and label-free quantitative proteomics', Molecular and Cellular Proteomics, 9, (6) pp. 1296-1313. ISSN 1535-9476 (2010) [Refereed Article]

DOI: 10.1074/mcp.M000014-MCP201 [eCite] [Details]

Citations: Scopus - 63Web of Science - 62

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2010Zreiqat H, Belluoccio D, Smith MM, Wilson R, Rowley LA, et al., 'S100A8 and S100A9 in experimental osteoarthritis', Arthritis Research and Therapy, 12, (1) Article R16. ISSN 1478-6362 (2010) [Refereed Article]

DOI: 10.1186/ar2917 [eCite] [Details]

Citations: Scopus - 58Web of Science - 56

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2009Rajpar MH, McDermott B, Kung L, Eardley R, Knowles L, et al., 'Targeted induction of endoplasmic reticulum stress induces cartilage pathology', Plos Genetics, 5, (10) Article e1000691. ISSN 1553-7390 (2009) [Refereed Article]

DOI: 10.1371/journal.pgen.1000691 [eCite] [Details]

Citations: Scopus - 114Web of Science - 115

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2009Wilson R, Whitelock JM, Bateman JF, 'Proteomics makes progress in cartilage and arthritis research', Matrix Biology: Clinical and Experimental, 28, (3) pp. 121-128 . ISSN 0945-053X (2009) [Refereed Article]

DOI: 10.1016/j.matbio.2009.01.004 [eCite] [Details]

Citations: Scopus - 20Web of Science - 21

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2008Wilson R, Bateman JF, 'A robust method for proteomic characterization of mouse cartilage using solubility-based sequential fractionation and two-dimensional gel electrophoresis', Matrix Biology: Clinical and Experimental, 27, (8) pp. 709-712. ISSN 0945-053X (2008) [Refereed Article]

DOI: 10.1016/j.matbio.2008.07.007 [eCite] [Details]

Citations: Scopus - 20Web of Science - 19

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2008Wilson R, Bateman JF, 'Cartilage proteomics: Challenges, solutions and recent advances', Proteomics Clinical Applications , 2, (2) pp. 251-263. ISSN 1862-8346 (2008) [Refereed Article]

DOI: 10.1002/prca.200780007 [eCite] [Details]

Citations: Scopus - 6Web of Science - 6

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2008Wilson R, Belluoccio D, Bateman JF, 'Proteomic analysis of cartilage proteins', Methods: A Companion to Methods in Enzymology, 45, (1) pp. 22-31. ISSN 1046-2023 (2008) [Refereed Article]

DOI: 10.1016/j.ymeth.2008.01.008 [eCite] [Details]

Citations: Scopus - 30Web of Science - 28

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2008Wilson R, Belluoccio D, Little CB, Fosang AJ, Bateman JF, 'Proteomic characterization of mouse cartilage degradation in vitro', Arthritis and Rheumatism, 58, (10) pp. 3120-3131. ISSN 0004-3591 (2008) [Refereed Article]

DOI: 10.1002/art.23789 [eCite] [Details]

Citations: Scopus - 51Web of Science - 52

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2006Allen JM, Bateman JF, Hansen U, Wilson R, Bruckner P, et al., 'WARP is a novel multimeric component of the chondrocyte pericellular matrix that interacts with perlecan', Journal of Biological Chemistry, 281, (11) pp. 7341-7349. ISSN 0021-9258 (2006) [Refereed Article]

DOI: 10.1074/jbc.M513746200 [eCite] [Details]

Citations: Scopus - 37Web of Science - 33

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2006Belluoccio D, Wilson R, Thornton DJ, Wallis TP, Gorman JJ, et al., 'Proteomic analysis of mouse growth plate cartilage', Proteomics, 6, (24) pp. 6549-6553. ISSN 1615-9853 (2006) [Refereed Article]

DOI: 10.1002/pmic.200600191 [eCite] [Details]

Citations: Scopus - 30Web of Science - 30

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2005Bateman JF, Wilson R, Freddi S, Lamande SR, Savarirayan R, 'Mutations of COL10A1 in Schmid metaphyseal chondrodysplasia', Human Mutation, 25, (6) pp. 525-534. ISSN 1059-7794 (2005) [Refereed Article]

DOI: 10.1002/humu.20183 [eCite] [Details]

Citations: Scopus - 60Web of Science - 53

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2005Wilson R, Freddi S, Chan D, Cheah KS, Bateman JF, 'Misfolding of collagen X chains harboring Schmid metaphyseal chondrodysplasia mutations results in aberrant disulfide bond formation, intracellular retention, and activation of the unfolded protein response', Journal of Biological Chemistry, 280, (16) pp. 15544-15552 . ISSN 0021-9258 (2005) [Refereed Article]

DOI: 10.1074/jbc.M410758200 [eCite] [Details]

Citations: Scopus - 55Web of Science - 55

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2002Wilson R, Freddi S, Bateman JF, 'Collagen X chains harboring Schmid metaphyseal chondrodysplasia NC1 domain mutations are selectively retained and degraded in stably transfected cells', Journal of Biological Chemistry, 227, (15) pp. 12516-12524. ISSN 0021-9258 (2002) [Refereed Article]

DOI: 10.1074/jbc.M112044200 [eCite] [Details]

Citations: Scopus - 28Web of Science - 29

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1999Ashworth JL, Kelly V, Wilson R, Shuttleworth CA, Kielty CM, 'Fibrillin assembly: dimer formation mediated by amino-terminal sequences', Journal of Cell Science, 112, (20) pp. 3549-3558. ISSN 0021-9533 (1999) [Refereed Article]

DOI: 10.1242/jcs.112.20.3549 [eCite] [Details]

Citations: Web of Science - 41

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1998Bulleid NJ, Wilson RR, Lad U, 'A cautionary note when using pepsin as a probe for the formation of a collagen triple helix', Matrix Biology: Clinical and Experimental, 17, (3) pp. 233-236. ISSN 0945-053X (1998) [Refereed Article]

DOI: 10.1016/S0945-053X(98)90062-2 [eCite] [Details]

Citations: Scopus - 2Web of Science - 2

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1998Wilson R, Lees J, Buleid NJ, 'Protein disulfide isomerase acts as a molecular chaperone during the assembly of procollagen', Journal of Biological Chemistry, 273, (16) pp. 9637-9643. ISSN 0021-9258 (1998) [Refereed Article]

DOI: 10.1074/jbc.273.16.9637 [eCite] [Details]

Citations: Scopus - 134Web of Science - 123

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1996Bulleid NJ, Wilson R, Lees J, 'Type-III procollagen assembly in semi-intact cells: Chain association, nucleation and triple-helix folding do not require formation of inter-chain disulphide bonds but triple-helix nucleation does require hydroxylation', Biochemical Journal, 317 pp. 195-202. ISSN 0264-6021 (1996) [Refereed Article]

DOI: 10.1042/bj3170195 [eCite] [Details]

Citations: Scopus - 62Web of Science - 62

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1995Wilson R, Allen AJ, Oliver J, Brookman JL, High S, et al., 'The translocation, folding, assembly and redox-dependent degradation of secretory and membrane proteins in semi-permeabilized mammalian cells', Biochemical Journal, 307, (3) pp. 679-687. ISSN 0264-6021 (1995) [Refereed Article]

DOI: 10.1042/bj3070679 [eCite] [Details]

Citations: Scopus - 133Web of Science - 132

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Chapter in Book

(1 outputs)
YearCitationAltmetrics
2000Wilson RR, Bulleid NJ, 'Semi-permeabilized cells to study procollagen assembly', Extracellular Matrix Protocols, Humana Press, CH Streuli and ME Grant (ed), New Jersey, USA, pp. 1-9. ISBN 978-0-8960-3624-6 (2000) [Research Book Chapter]

[eCite] [Details]

Conference Publication

(37 outputs)
YearCitationAltmetrics
2017Karu N, Patchett AL, Wilson R, Hamede Ross RK, Jones Menna, et al., 'Application of metabolomics and proteomics for biomarker discovery and development of therapies for the transmissible cancer, Tasmanian Devil Facial Tumour Disease', February 2nd-5th 2017, Lorne, VIC (2017) [Conference Edited]

[eCite] [Details]

Co-authors: Karu N; Patchett AL; Hamede Ross RK; Jones Menna; Lyons AB; Woods GM

2016De Paoli AG, Wilson RR, Vervaart P, Dargaville PA, Jacobson GA, 'Identifying novel markers of late onset neonatal sepsis using proteomic analysis', Proceedings of the 20th Annual Congress of the Perinatal Society of Australia and New Zealand, May 22nd-25th, 2016, Townsville, Australia (2016) [Conference Extract]

[eCite] [Details]

Co-authors: De Paoli AG; Dargaville PA; Jacobson GA

2016Karu N, McKercher CM, Nichols DS, Davies NW, Wilson RR, et al., 'From non-targeted metabolomics to quantitative analysis of uremic compounds in chronic kidney disease', Proceedings of The Australian & New Zealand Metabolomics Conference, 31st March - 1st April, 2016, Melbourne, Australia (2016) [Conference Extract]

[eCite] [Details]

Co-authors: Karu N; McKercher CM; Nichols DS; Davies NW; Hilder EF; Shellie RA; Jose MD

2016Karu N, Wilson RR, Hamede Ross RK, Jones Menna, Woods GM, et al., 'Discovery of serum biomarkers for Tasmanian Devil cancer (DFTD)', Proceedings of The Australian & New Zealand Metabolomics Conference, 31st March - 1st April, 2016, Melbourne, Australia (2016) [Conference Extract]

[eCite] [Details]

Co-authors: Karu N; Hamede Ross RK; Jones Menna; Woods GM; Hilder EF; Shellie RA

2016Wilson RR, Golub SB, Angelucci C, Bateman JF, Fosang AJ, 'Novel elements of the chondrocyte stress response identified using an in vitro model of mouse cartilage degradation', 4th-7th February, 2016, Victoria, Australia (2016) [Conference Edited]

[eCite] [Details]

2015Nuez Ortin W, Carter CG, Nichols PD, Wilson RR, 'Increasing deposition efficiency of N-3 LC-PUFA in Altlantic Salmon smolt using high DHA and ALA oils', Oct 20th-23rd, Rotterdam, Holland (2015) [Conference Edited]

[eCite] [Details]

Co-authors: Nuez Ortin W; Carter CG

2015Wilson RR, Golub SB, Angelucci C, Bateman JF, Fosang AJ, 'Novel elements of the chondrocyte stress response identified using an in vitro model of mouse cartilage degradation', 1st-4th November, 2015, Hobart, Tasmania, Australia (2015) [Conference Edited]

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2014Fosang AJ, Golub S, Last K, Lees S, Wilson RR, et al., 'Bioactivity in an aggrecan 32mer fragment is mediated via toll-like receptors', Proceedings of the 9th Pan Pacific Connective Tissue Societies Symposium, November 24-27 2013, Hong Kong, pp. 0076. (2014) [Conference Extract]

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2014Nuez Ortin W, Carter CG, Nichols PD, Wilson RR, 'Method development for protein enrichment in gel-free proteomic analysis of whole fish', 16th International Symposium on Fish Nutrition and Feeding, May 25-30 2014, Cairns, Australia (2014) [Conference Extract]

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Co-authors: Nuez Ortin W; Carter CG

2014Wilson RR, Golub SB, Angelucci C, Karpievitch YV, Bateman JF, et al., 'Proteomic analysis of cytokine-induced cartilage degradation in normal cartilage and cartilage lacking ADAMTS-5 activity', Proceedings of the 38th Annual Scientific Meeting of the Matrix Biology Society of Australia and New Zealand, 26th-29th October 2014, Queenscliff, Victoria, pp. 39. (2014) [Conference Extract]

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Co-authors: Karpievitch YV

2013Feng S, Bowman JP, Powell S, Wilson RR, 'The light-driven proton pump proteorhodopsin promotes growth of sea-ice psychrophile during salinity stress', The Australian Society for Microbiology Annual Scientific Meeting, 7-10 July 2013, Adelaide, South Australia (2013) [Conference Extract]

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Co-authors: Feng S; Bowman JP; Powell S

2013Feng S, Powell S, Wilson RR, Bowman JP, 'Light stimulated growth of proteorhodopsin bearing sea-ice psychrophile Psychroflexus torquis is salinity-dependent', Strategic Science in Antarctica 2013 Conference, 24-28 June 2013, Hobart, Australia (2013) [Conference Extract]

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Co-authors: Feng S; Powell S; Bowman JP

2013Karu N, Davies NW, Wilson RR, Shellie RA, Thompson RS, et al., 'Mass spectrometry for the determination of renal disease biomarkers in urine', Proceedings of the 24th meeting of the Australian and New Zealand Society for Mass Spectrometry, 2-6 February 2013, Melbourne, Australia (2013) [Conference Extract]

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Co-authors: Karu N; Davies NW; Shellie RA; McMorran BJ; Jose MD; Foote SJ; Hilder EF

2013Kocharunchitt C, Porteus BF, Wilson RR, Ross T, Bowman JP, 'The protein landscape of Listeria monocytogenes ScottA within its supraoptimal temperature growth range reveals a weakness to oxidative stress', 5th Congress of European Microbiologists (FEMS 2013), 21-25 July 2013, Liepzig, Germany (2013) [Conference Extract]

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Co-authors: Kocharunchitt C; Porteus BF; Ross T; Bowman JP

2013Wilson RR, 'Comparative Proteomic Analysis of Normal, Collagen VI null and Collagen IX Null Mouse Cartilage', April 7th-April 12th 2013, GRC, Les Diablerets, Switzerland (2013) [Conference Edited]

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2013Wilson RR, Norris EL, Dave K, Brachvogel B, Zaucke M, et al., 'Analysis of cartilage development in normal mice and in mice lacking collagen IX or COMP', Feb 7th-Feb 10th 2013, Lorne, Victoria, Australia (2013) [Conference Edited]

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2012Nikolic S, Edwards LM, Wilson RR, Hare JL, Marwick TH, et al., 'Spironolactone reduces aortic stiffness in people with a hypertensive response to exercise via the blood pressure dependent effects of canrenoate', Proceedings of the 12th meeting of the Association for Research into Arterial Structure and Physiology, October 2012, Vienna, Austria (2012) [Conference Extract]

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Co-authors: Nikolic S; Edwards LM; Marwick TH; Sharman JE

2012Nikolic S, Edwards LM, Wilson RR, Hare JL, Marwick TH, et al., 'Effects of downstream drug metabolites of spironolactone on aortic stiffness and ambulatory blood pressure', Proceedings of the 24th Scientific Meeting of the International Society of Hypertension, September 2012, Sydney, Australia (2012) [Conference Extract]

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Co-authors: Nikolic S; Edwards LM; Marwick TH; Sharman JE

2011Wilson R, Brachvogel B, Gorman J, Bateman J, 'Comparative proteomic analysis of normal mouse cartilage and cartilage lacking collagen IX: Altered extracellular matrix composition and interactions', 7th International Conference on the Biology of Proteoglycans, 16-20 October 2011, Sydney, Australia (2011) [Conference Extract]

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2010Wilson R, 'New insights into cartilage biology and pathology using mouse cartilage proteomics', ICRS Abstracts 2011, 26-29 September 2010, Barcelona, Spain (2010) [Plenary Presentation]

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2010Wilson R, Diseberg A, Gorman J, Bateman J, 'Novel aspects of chondrocyte biology and changes in the cartilage ECM revealed by proteomic analysis of mouse cartilage development in vivo', Australian Health and Medical Research Congress 2010 Abstracts, 12-15 November 2010, Melbourne, Australia (2010) [Conference Extract]

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2010Wilson R, Diseberg A, Gorman J, Bateman J, 'Proteomic profiling of cartilage ECM formation and maturation using sequential protein extraction and quantitative mass spectrometry', 17th Meeting of the Federation of European Connective Tissues Societies, 3-7 July 2010, Davos, Switzerland (2010) [Conference Extract]

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2010Wilson R, Diseberg A, Zivkovic S, Gordon L, Tatarczuch L, et al., 'Proteomic profiling of cartilage extracellular matrix maturation', W B SAUNDERS CO LTD, 18-21 September 2008, Brussels, BELGIUM, pp. S225-S225. ISSN 1063-4584 (2010) [Conference Edited]

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2009Wilson RR, Diseberg A, Gorman J, Zivkovic S, Bateman J, 'Proteomic characterization of cartilage matrix synthesis and breakdown', 8th Pan-Pacific Connective Tissue Societies Symposium , 4-7 June 2009, Yukosuka, Japan (2009) [Conference Extract]

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2008Belluoccio D, Wilson R, Rowley L, Bateman J, 'Expression profiling of mouse femoral head cultures stimulated with interleukin-1alpha or retinoic acid', WB Saunders, 18-21 September 2008, Rome, Italy, pp. S101. ISSN 1063-4584 (2008) [Conference Edited]

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2008Boot-Handford R, Rajpar H, McDermott C, Wilson R, Bateman J, et al., 'ER stress disrupts chondrocyte differentiation; phenocopying a metaphyseal chondrodysplasia by introducing targeted ER stress in vivo', Federation of European Connective Tissues Societies, 9-13 July 2008, Marseille, France (2008) [Conference Edited]

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2008Wilson R, Bateman J, 'A robust method for proteomic characterization of mouse cartilage using solubility-based sequential fractionation and 2-D electrophoresis', WB Saunders, September 18-21, 2008, Rome, Italy, pp. S205. ISSN 1063-4584 (2008) [Conference Edited]

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2008Wilson R, Belluoccio D, Little C, Fosang A, Bateman J, 'Proteomic characterization of mouse cartilage degradation in vitro', WB Saunders, 18-21 September 2008, Rome, Italy, pp. S205-S206. ISSN 1063-4584 (2008) [Conference Edited]

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2008Wilson R, Belluoccio D, Little C, Fosang A, Bateman J, 'Proteomic profiling of cartilage degradation in vitro', Federation of European Connective Tissues Societies, 9-13 July 2008, Marseille, France (2008) [Conference Edited]

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2008Wilson R, Belluoccio D, Little C, Fosang A, Bateman J, 'Novel methods for cartilage proteomic analysis', 32nd Annual Scientific Meeting of the Matrix Biology Society of Australia and New Zealand, 13-16 October 2008, Eattalong Beach, NSW, Australia (2008) [Conference Extract]

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2007Wilson R, Belluoccio D, Little C, Fosang A, Bateman J, 'Proteomic analysis of mouse cartilage degradation in vitro', 7th Pan-Pacific Connective Tissue Societies Symposium, 28 October - 1 November 2007, Cairns, Australia (2007) [Conference Extract]

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2006Wilson R, Belluoccio D, Bateman J, 'Proteomic identification of novel extracellular matrix components and cartilage protein fragments', 30th Annual Scientific Meeting of the Matrix Biology Society of Australia and New Zealand, 28 November - 1 December 2006, Melbourne, VIC, Australia (2006) [Conference Extract]

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2006Wilson RR, Belluoccio D, Bateman J, 'Proteomic analysis of mouse growth plate cartilage using microdissection and 2-D electrophoresis', MBSANZ/AHMRC, November 26- December 1, 2006, Melbourne, VIC, Australia (2006) [Conference Edited]

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2006Wilson RR, Freddi S, Bateman J, 'Schmid Metaphyseal Chondrodysplasia mutations in collagen X elicit the unfolded protein response', MPG, Febuary 12, 2006, Melbourne, VIC, Australia (2006) [Conference Edited]

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2005Wilson RR, Freddi S, Bateman J, 'Intracellular and extracellular consequences of collagen X misfolding', MBSANZ, September 29-October 2, 2005, Victor Harbor, SA, Australia ISBN 0958589267 (2005) [Conference Edited]

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2004Wilson RR, Freddi D, Chan D, Cheah K, Bateman J, 'Aberrant disulfide bond formation and endoplasmic reticulum stress is associated with disease-causing collagen X mutations', FECTS, July 9-13, 2004, Sicily, Italy (2004) [Conference Edited]

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2002Wilson RR, Freddi D, Bateman J, 'Intracellular retention and degradation of collagen X chains harboring disease-causing mutations', FECTS, July 27-31, 2002, Brighton, UK (2002) [Conference Edited]

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Grants & Funding

Funding Summary

Number of grants

18

Total funding

$2,589,837

Projects

Discovery of devil facial tumour antigens from new sources for vaccine development (2024 - 2025)$48,938
Description
Long non-coding RNA (lncRNA) and alternative RNA splicing are increasingly recognised as major sources of tumour-specific antigens in human cancers. This project will discover novel proteins that are aberrantly expressed from lncRNA and alternative RNA splicing and evaluate the potential of these novel proteins as targets for the current DFTD vaccine.
Funding
University of Tasmania Foundation Inc ($48,938)
Scheme
Grant-Dr Eric Guiler Tasmanian Devil Research Gran
Administered By
University of Tasmania
Research Team
Flies AS; Patchett AL; Wilson RR
Period
2024 - 2025
Experimental Platforms for Aquaculture Production (2022 - 2027)$1,177,116
Description
The principle aim is to build a translational experimental approach to identify and address critical knowledge gaps in Atlantic salmon aquaculture production by working closely with industry partners. This will consider the impact of key environmental variables, relevant to current and future offshore expansion, on commercial salmon performance. Strong engagement by the project team and students with partners, including placements with commercial organisations, will ensure their capability and career development will meet industry needs. Successful outcomes will come from establishing and validating the translation of data at the research-commercialnexus to support the industry in managing a rapidly changing climate.
Funding
Blue Economy CRC Co ($1,177,116)
Scheme
General Projects
Administered By
University of Tasmania
Research Team
Carter CG; Amoroso G; Thompson AM; Henderson AD; Wilson RR; Adams LR; Poutney D; Goodrich HR
Period
2022 - 2027
New therapeutic approaches for genetic skeletal disorders (2021 - 2023)$30,930
Description
Genetic skeletal disorders are a significant disease burden and are commonly caused by mutations in the genes for extracellular matrix proteins. Recent studies have shown that endoplasmic reticulum stress signalling resulting from mutations that cause protein misfolding and intracellular retention are major contributors to the pathology. Archetypical of these are collagen mutations causing the debilitating disorders of bone, osteogenesis imperfecta (OI), and cartilage, spondyloepiphyseal dysplasia (SED). Our studies will test the effect of drugs that can ameliorate the cell stress signalling in other conditions and we will also screen libraries to identify novel drugs. We have validated mouse models of OI and SED and induced pluripotent stem cell (iPSC) lines with patient mutations to produce bone and cartilage disease in a dish models. Our first line approach will be to use the mouse models to test drugs that stimulate mutant collagen breakdown to reduce mutant load and cell stress signalling. Our recent data treating mice with the autophagy-stimulating drug, rapamycin, showed the promise of this approach. OI mouse trabecular bone was improved, but there were unacceptable off-target effects on cartilage and bone growth. This highlights the need to test additional, more specific drugs. Effects of drugs on cartilage and bone pathophysiology will be assessed by histology, micro-CT, biomechanics and detailed biochemical analysis. The second phase of our research will be to use iPSC-derived patient cartilage and bone in vitro models to screen for new drugs in a library of FDA-approved drugs. Fluorescently tagged collagens (CRISPR-Cas9) in the cartilage and bone cells will allow us to use high-content imaging to screen for the effect of the drug candidates on mutant and normal collagen trafficking and degradation. Promising drug candidates will then be further tested in our in vitro models.
Funding
Murdoch Children's Research Institute ($30,930)
Scheme
Contract Research
Administered By
University of Tasmania
Research Team
Wilson RR
Period
2021 - 2023
Development of an early diagnostic liquid biopsy for DFT2 (2021)$50,000
Description
The two genetically independent transmissible cancers affecting Tasmanian devils (DFT1 and DFT2) can be only differentially diagnosed once tumours have appeared. However, DFT1 and DFT2 cannot be diagnosed when tumours are not available to sample. This project will validate a differential diagnosis biomarker for DFTD in serum samples and will explore whether it can serve as an early DFT2 biomarker.
Funding
University of Tasmania Foundation Inc ($50,000)
Scheme
Grant-Dr Eric Guiler Tasmanian Devil Research Gran
Administered By
University of Tasmania
Research Team
Lyons AB; Espejo CI; Hamede Ross RK; Wilson RR; Patchett AL
Year
2021
The impact of culture condition on biochemical egg content in Tasmanian Atlantic salmon (2020)$5,856
Description
In an aquaculture setting, female Tasmanian salmon (Salmo salar) broodstock may be managed using one of two strategies in the lead up to manual strip spawning (egg collection). The first strategy utilises indoor recirculating aquaculture systems (RAS), which allows fine control of water quality parameters, including temperature. For the second strategy, fish are maintained in outdoor flow-through (FT) systems where it is not possible/practical to control water temperature. While there are many advantages to using RAS, the significant initial investment required, and the ongoing cost of maintaining these systems has been a barrier to achieving 100% RAS during the (freshwater) FW phase in Tasmania. While the running costs are lower for FT systems, the downside is that fish may be exposed to higher-than optimal temperatures in summer, which has a deleterious impact on physiology and subsequent reproductive performance.Despite the importance of egg quality for offspring survival and performance, egg content at spawning/stripping is a relatively under-explored area of fish biology. For example, significant differences in egg protein and fatty acid abundance and diversity have been noted for some fish species between batches of high and low quality eggs, yet there have been no studies characterising the impact of high maternal temperature on these parameters in fish. Without detailed information regarding deficiencies or imbalances in egg content, development of mitigation strategies (e.g. diet optimisation) would largely be guesswork. Therefore, the overarching aim of this project is to understand how culture conditions impact Atlantic salmon egg protein and fatty acid content.
Funding
Petuna Aquaclture Pty Ltd ($5,856)
Scheme
Contract Research
Administered By
University of Tasmania
Research Team
Anderson KC; Adams LR; Adams MB; Wilson RR
Year
2020
Identifying shared mechanisms in response to radiotherapy (2020)$18,980
Description
Radiotherapy remains one of the most frequently utilised therapies in cancer treatment today. However, despite the frequency of its use, many patients experience treatment resistance and disease recurrence. It is therefore essential to identify predictive markers of response that would enable patients unlikely to benefit from radiotherapy to be identified and spared an ineffective treatment and its associated side effects. This project will use an in vitro model to identify shared drivers of resistance and potential predictive biomarkers between cancers originating from different sites (prostate vs brain). It will involve RNA-seq, proteomics profiling and analysis of 3D spheroids in response to radiotherapy.
Funding
Cancer Council of Tasmania ($18,980)
Scheme
Grant-Small
Administered By
University of Tasmania
Research Team
Brettingham-Moore KH; Azimi I; Wilson RR
Year
2020
Cawthron Collaborative Research for three PhD Operating & TAG Travel Costs (2018 - 2021)$89,650
Description
This is a PhD project located at IMAS and funded by Cawthron Institute, NZ from a MBIE grant.This is an exciting opportunity to link in with international research on aquaculture of a salmonid species (chinook salmon) and to gain skills and experience in forward looking technology around molecular biology and recirculation aquaculture systems. The research will focus on understanding the impact of genome (family) and environmental change under controlled conditions on chinook salmon. Environmental variables include temperature, salinity and pH because these impact on local NZ industry performance and sustainability. Research will advance fundamental knowledge about the chinook salmon proteome and how proteomics can be used to understand drivers of growth and growth efficiency. The project will develop proteomic based methods and relate this to other molecular based approaches. The research will contribute to sustainable aquaculture by understanding what happens to salmon when exposed to various situations that may be encountered in aquaculture. It will equip you with a range of new skills from maintenance of fish to advance molecular analyses.
Funding
Cawthron Institute New Zealand ($89,650)
Scheme
Contract Research
Administered By
University of Tasmania
Research Team
Carter CG; Bridle AR; Wilson RR; Nowak BF; Bowman JP
Period
2018 - 2021
Identification of devil facial tumour-associated antigens for vaccine development (2018 - 2019)$34,256
Description
The current DFTD vaccine can induce anti-DFTD immune responses, but the scalability and efficacy of the vaccine needs to be improved to deliver a broad conservation impact. This proposal builds on ongoing vaccine research to identify tumour-associated antigens that can be used to produce a highly replicable and scalable DFTD vaccine.
Funding
University of Tasmania Foundation Inc ($34,256)
Scheme
Grant-Dr Eric Guiler Tasmanian Devil Research Gran
Administered By
University of Tasmania
Research Team
Flies AS; Woods GM; Lyons AB; Wilson RR
Period
2018 - 2019
Exosome proteomics to detect biomarkers of erythropoietin (EPO) use in athletes (2018)$186,727
Description
Erythropoietin (EPO) is a 30 kDa glycoprotein hormone that controls red blood cell production, and is typically used to treat anemia resulting from chronic kidney disease. EPO is mainly produced in the kidneys, with production stimulated by hypoxia, with this hypoxia usually determined by red blood cell levels in the circulation. EPO is secreted into the plasma and binds to targets in the bone marrow (a 72 kDa receptor) which increases the ability of the marrow to produce more erythrocytes, and hence oxygen carrying capacity. There are a rapidly growing number of erythropoietin stimulating agents (ESAs) prohibited under S2 of the WADA Prohibited List, including erythropoietin and darbepoetin-alfa, as well as a plethora of hypoxia-inducible factor stabilisers (HIFs), EPO mimetic peptides such as peginesatide, and new third generation ESAs entering the market such as continuous erythropoietin receptor activators (CERA) including methoxy polythyethylene glycol-epoetin beta (Micera). This diverse range of compounds and development of new third generation agents highlights the difficulty in detection of these agents, and supports the rationale for platform -omics technologies for the development of biomarkers for detection of ESAs. There is conclusive evidence that EPO and ESAs more generally are performance enhancing in endurance sport. Sports such as distance running, cycling and cross country skiing where performance is reliant on delivery of oxygen to the skeletal muscles. The performance enhancing effects of recombinant human EPO (rhEPO) administered at relatively modest doses can result in a 6-12% increase in maximum oxygen carrying capacity, and also increase the time to exhaustion by as much as 50% at a given oxygen carrying capacity.rhEPO doping detection is problematic for many reasons. Firstly, EPO is endogenous and discrimination between the body's natural EPO and increased EPO through doping with administration of rhEPO is difficult; endogenous EPO may also be raised through doping with a variety of ESAs as well as indirect methods using the ever expanding class of HIFs. Secondly, the effects are profound with significant performance gains in endurance sports even after a washout of the EPO doping agent in terms of weeks. The specific detection of ESAs is currently based on two different approaches, the direct detection of exogenous agents and indirect detection of specific biomarkers, which is particularly promising with newer -omics approaches. Indirect evidence of rhEPO use is based on analysis of blood parameters including hemoglobin hematocrit and is contained in the Athlete Biologic Passport (ABP) but is limited in ability to provide smoking gun conclusive evidence. Although WADA publishes criteria in an attempt to ensure harmonization between laboratories, alarmingly, a significant study demonstrated very poor agreement between two accredited laboratories which was worse during the maintenance and washout periods.The project will study the proteome of extracellular vesicles called exosomes, with the objective of identifying biomarkers of rhEPO use. The application of proteomics to exosomes isolated from blood is an exciting area research. By applying nanoflow LC-MS/MS proteomics approaches to exosomes, one of the greatest limitation of current blood proteomics for doping biomarkers is overcome - the avoidance of high abundance plasma proteins. The study will consist of a physiological intervention trial, with highly trained male athletes visiting the NEXS clinic (Copenhagen) two weeks (-2), and one week (-1) before baseline (0) where subjects will undergo treatment with microdosed rhEPO (20 IU/kg every second day for two weeks), and subsequent visits at +1, +2, +3 weeks following treatment. Blood and urine will both be collected for exosome proteomics at each visit, along with a standard set of relevant exercise physiology tests (VO2). Exosomes will be isolated using the Total Exosome Isolation kit (Invitr
Funding
World Anti-Doping Agency ($186,727)
Scheme
Grant
Administered By
University of Tasmania
Research Team
Jacobson GA; Wilson RR; Hostrup M; Bangsbo J
Year
2018
Advanced high resolution biomolecular analysis facility for Tasmania (2018)$350,790
Description
This proposal seeks support for an advanced, multi-purpose mass spectrometry platform for high-throughput and targeted biomolecular analysis, including proteomics and metabolomics. The intended purpose of the proposed infrastructure is to provide a centralised state-of-the-art facility that supports internationally competitive research programs in plant science, agricultural research, food safety, animal and human health research and separation science at the University of Tasmania (UTAS) and within the broader Tasmanian scientific community. Theanticipated benefit is a greatly enhanced capacity for leading edge research of national significance that alignswith the UTAS strategic research plan and national priorities.
Funding
Australian Research Council ($350,790)
Scheme
Grant-Linkage Infrastructure
Administered By
University of Tasmania
Research Team
Smith SM; Paull B; Woods GM; King AE; Wilson RR
Year
2018
Grant Reference
LE180100059
Proteomics for Tasmanian devils: a DFTD pre-clinical test (2017)$15,000
Description
Proteins within the circulatory system offer insight into the pathophysiology of an individual, and protein biomarkers are frequently the basis for clinical diagnostic tests. This project will use proteomics to compare serum from non-infected and DFTD-infected Tasmanian devils to identify a DFTD-specific protein signature that could be used to develop a diagnostic test for early detection of DFTD.
Funding
University of Tasmania Foundation Inc ($15,000)
Scheme
Grant-Dr Eric Guiler Tasmanian Devil Research Gran
Administered By
University of Tasmania
Research Team
Wilson RR; Hamede Ross RK; Woods GM
Year
2017
Bioplatforms Australia (BPA) - collaborative research (2016)$15,000
Description
Funds will be used to procure services from BPA that will support proteomics and research projects on, respectively, molecular mechanisms of DFTD and the physiological response of diatoms to environmental stresses.
Funding
Bioplatforms Australia Ltd ($15,000)
Scheme
Contract Research
Administered By
University of Tasmania
Research Team
Wilson RR; Foo E; King AE; Tovar Lopez CD; Martin AR
Year
2016
Prevalence and virulence of an emerging bacterial pathogen of Tasmanian cystic fibrosis patients (2015)$11,100
Description
Pandoraea, an emerging bacterial pathogen of cystic fibrosis is difficult to identify, is of unknown clinical significance and was recently isolated from a Tasmanian CF patient. we will investigate the prevalence of Pandoraea in Tasmanian CF patients, describe its virulence potential and investigate its susceptilility to our new antimicrobial therapy.
Funding
Royal Hobart Hospital Research Foundation ($11,100)
Scheme
Grant-Clinical Research
Administered By
University of Tasmania
Research Team
Roddam LF; Ambrose M; Beggs S; Cooley MA; Malley RC; Warren SJ; Wilson RR; McEwan B
Year
2015
Metabolomics for Tasmanian devil DFTD biomarkers discovery (2015)$33,000
Description
The project aims to create a databank of metabolic profiles from 100 Tasmanian devil serum samples using high-resolution instrumentation and then probe this databank to unravel the metabolic differences between healthy and DFTD animals.
Funding
University of Tasmania Foundation Inc ($33,000)
Scheme
Grant-Dr Eric Guiler Tasmanian Devil Research Gran
Administered By
University of Tasmania
Research Team
Shellie RA; Karu N; Wilson RR; Hamede Ross RK; Hilder EF
Year
2015
Proteomic analysis of protein growth and n-3 PUFA synthesis in Atlantic salmon (2013 - 2015)$35,000
Funding
CSIRO-Commonwealth Scientific & Industrial Research Organisation ($35,000)
Scheme
Scholarship-Top-Up
Administered By
University of Tasmania
Research Team
Carter CG; Wilson RR
Period
2013 - 2015
Resolving Dissolved Organic Matter: New Multi-dimensional Separation Approaches. (2013 - 2015)$480,000
Description
This project explores the origin and nature of complex dissolved organic (carbon) matter (DOM), through the development and application of new multi-dimensional analytical technology. Through greater understanding of the character of this complex material, the project sheds new light upon the role such oceanic carbon sinks play in global carbon cycles. Specifically, the project utilises the only recently available high-performance counter current chromatography (HPCCC) as a fractionation tool for collected DOM samples, prior to fractional analysis using orthoganol chromatographic techniques coupled to high resolution mass spectrometry, and two-dimensional nuclear magnetic resonance spectroscopy (2DNMR).
Funding
Australian Research Council ($480,000)
Scheme
Grant-Discovery Projects
Administered By
University of Tasmania
Research Team
Nesterenko PN; Haddad PR; Davies NW; Wilson RR; Kelleher B
Period
2013 - 2015
Grant Reference
DP130101518
2013: Cartilage biology and pathology gordon research conference, Switzerland 7-12 April 2013 (2013)$2,500
Funding
University of Tasmania ($2,500)
Scheme
Grant-Conference Support Scheme
Administered By
University of Tasmania
Research Team
Wilson RR
Year
2013
Development of Protein Analysis Methods to Facilitate Proteomic Analysis by Mass Spectometry (2011)$4,994
Funding
University of Tasmania ($4,994)
Scheme
Grant-New Appointees Research Grant Scheme (NARGS)
Administered By
University of Tasmania
Research Team
Wilson RR
Year
2011

Research Supervision

Current

7

Completed

6

Current

DegreeTitleCommenced
PhDEffects of Insulin on Muscle Performance, Exercise Recovery and the Interrelationship with Beta2-Agonists Drugs2020
PhDMemory Consolidation and Reconsolidation of Aversive and Pleasurable Memories in Planaria2021
PhDStem Cell Models of the Blood-brain Barrier2022
PhDBenchmarking Atlantic Salmon Performance2023
PhDUnderstanding and Manuipulating Protein Synthesis in Fava Beans to Produce High Protein Fava Beans for an Alternative Protein Future2023
PhDDrug Discovery in Obesity Research: asperuloside a new compound for weight loss2023
PhDResponse of Escherichia coli to Temperature Stress Relevant to the Meat Cold Chain2023

Completed

DegreeTitleCompleted
PhDLimits to Life: What controls maximum growth rates?
Candidate: Cameron Angus Macdonald		2023
PhDUnderstanding Molecular Mechanisms Drive Feed Efficiency in Chinook Salmon Farmed in Freshwater and Seawater using Proteomics and Metabolomics
Candidate: Mohammad Esmaeili		2022
PhDImmunological Tools and Early Diagnostic Approaches to Monitor the Effects of Devil Facial Tumour Disease on Wild Tasmanian Devils
Candidate: Camila Ignacia Espejo Benavides		2021
PhDStomata Operation in Halophytes
Candidate: Fatemeh Rasouli		2020
PhDProteomic and Phenotypic Approaches to Assess Nutritional Physiology in Atlantic Salmon
Candidate: Waldo Gabriel Nuez-Ortin		2016
PhDSpirulina: Dual-Purpose Lamb Supplement - Breed and Sex Effects on Productivity and Product Quality
Candidate: Benjamin William Behrens Holman		2013